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Signaling Pathways Metabolic Enzyme/Protease Glutathione S-transferase Glutathione S-transferase Glutathione transferases

Predominately Cardiac Effects: Diltiazem (Cardiazem),Verapamil (Isoptin, Calan) moderate vasodilation moderate decreased contractility Predominately Vascular Effects: Amlodipine (Norvasc), Nicardipine (Cardene), Nifedipine (Procardia, Adalat) marked vasodilation minimal effects on contractility minimal or no effects on AV conduction Absorption, Metabolism, Excretion Calcium channel blockers are well absorbed after oral administration

Acute hyperammonemic encephalopathy in adult onset ornithine transcarbamylase deficiency

10.3390/ijms19092487 71 KondouA.BegouO.DotisJ.KaravaV.PanterisE.TaparkouA.et al (2022)