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Animals were monitored daily for clinical signs, with regular measurements of body weight, food consumption and vital signs

Activation of this pathway increases the cells ability to neutralize ROS before they can damage proteins, lipids, or DNA

The translation of preclinical to clinical testing for molecularly-based compounds is limited by multiple factors including the appropriate scheduling and toxicity of the agent, the interpatient and intratumoral variability of the expression of the molecular target and its role as a predictor of treatment response, and molecular crosstalk among redundant, parallel intracellular signaling pathways (Haffty and Glazer, 2003)

It is essential to acknowledge that efflux contributes differently to tolerance, depending on both the drug class (efflux being particularly informative for azoles) and the fungal species, based on their transporter repertoire and expression time course