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Menichini et al

170 Gentiopicroside significantly attenuates weight loss and disease activity index scores in dextran sulfate sodium-induced colitis mice, restores intestinal tight junction protein expression, and improves colonic permeability

Additionally, early nonmotor symptomssuch as anosmia, REM sleep behavior disorder (RBD), and gastrointestinal dysfunctionare increasingly identified as prodromal indicators