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However, its true therapeutic efficacy will need to be further validated in biomarker-selected patient populations

119 Additional studies have shown that aggregated mutant SOD1 has low Cu content both in cultured cells and in the spinal cord of transgenic SOD1 mice, regardless of the mutant proteins ability to bind Cu 120,121

Moreover, film samples were subjected to a photo-oxidative process under UV irradiation up to 11 hours and the oxidation level was monitored by means of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI TOF MS)