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This tolerance-building process is analogous to allergy immunotherapy, where repeated exposure to an allergen gradually desensitizes the immune system

Results: qPCR revealed that treatment with rivenprost markedly reduced the gene levels of fibronectin ( Fn1 ), a-smooth muscle actin ( Acta2 ), collagen 1A1 ( Col1a1 ), and tumor necrosis factor a ( Tnf ) in rat NASH PCLS

The DM-associated complications, such as high glucose levels, can stimulate ROS generation through PKC and NADPH-dependent pathways in various cells, such as aortic endothelial cells, smooth muscle cells, and renal mesangial cells (N