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By inhibiting the activity of Tyrosinase enzyme, making the skin white by inhibiting the process of melanin production

Proc Natl Acad Sci USA (2022) 119(6):e2117767119

Mice from each group were placed in water to elicit a fear of drowning

At the same time, most small-molecule and biologic drugs distribute widely in the circulation, while only a limited and often heterogeneous fraction reaches the tumor, resulting in insufficient and uneven local exposure [7]