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10.1016/j.taap.2016.08.027 Toxicol Appl Pharmacol

Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization

Although a single species is being considered, and as such it is impossible to infer with certainty any gene loss in the Holostei lineage, the absence of a SVCT1 gene, as here observed, would explain why GULO cannot be lost in this lineage

Besides, zinc is also involved in the inhibition of invasion and adhesion in malignant prostate cancer cell through several ways: strongly prevents the enzymatic activity of prostate-specific antigen (PSA) and suppresses the invasion of LNCaP cells, 360 reduces the expression of vascular endothelial growth factor (VEGF), 361 interleukin (IL)-6, IL-8, matrix metalloproteinase-9 (MMP9), intercellular adhesion molecule-1 (ICAM1), diminished the activity of urokinase-type plasminogen activator and aminopeptidase N (AP-N) 362 (Fig