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( On the other hand, platinum compounds such as oxaliplatin have a strong neurotoxicity compared to other anticancer drugs

Notably, the corresponding mechanistic relationships remain to be elucidated

In line with such results, also non-toxic digoxin-like synthetic derivatives (20,22-dihydrodigoxin-21,23-diol and digoxin-21-salicylidene) have been shown to specifically block IL-17 expression in human CD4 + T cells by inhibiting RORt activity 141