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The aberrant activity of these enzymes is closely linked with the pathogenesis of a wide range of diseases, not only cancers but also metabolic, inflammatory, and neurological disorders, underscoring the therapeutic relevance of targeting these pathways

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IDH mutations in glioma and acute myeloid leukemia

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Beyond NH 4 + , AAs represent a second major form of nitrogen exchange during cross-feeding

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doi:10.1016/j.juro.2008.10.015

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