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There is increasing evidence that these models share pathologic and biochemical characteristics seen in the more traditional models of focal and diffuse TBI, including hemorrhage, diffuse axonal injury, cortical and subcortical cell injury, metabolic disturbances/energy failure, inflammation, and oxidative stress

Inhibition of glutathione markedly enhanced H 2 O 2 - or ARS-induced cytotoxicity in HeLa and A549 cell lines but modestly enhanced the cytotoxicity of H 2 O 2 and even did not affect the cytotoxicity of ARS in HepG2 cells

This anti-epileptic effect is further verified in the clinical studies, Mao et al

Statements Author contributions TM conceived the manuscript