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In order to verify the performance of the MPTP-model, nigrostriatal degeneration was quantified through the TH immunohistochemistry in both putamen (optical density) and SNpc (number of TH-positive neurons)

To this end, we first simulated the TME by culturing CD8 + T cells with B16F10 cell supernatant, revealing that cystine supplementation in the supernatant prevented T-cell ferroptosis (Fig