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This is because benzyl alcohol loses its effectiveness as a preservative with repetitive use and exposure

in- hibits production of neurotransmitters by inhibiting: cal- cium-dependent neurotransmitter release [10], dihydro- teridine reductase [14], nitric oxide synthase [15], block- ing neurotransmitter amino acids [16], causes abnormal migration of neurons in the cerebral cortex [17] and hence continues to pose appreciable risk to human health as evidenced by the tragic epidemics of mercury poison- ing in Japan and Iraq [18]

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While there are some critical challenges that need to be addressed, curcumin exhibits numerous strengths, such as its traditional use for centuries