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ACh exerts tonic effects to maintain constriction of the lower esophageal sphincter, with ACh signaling compromised in a rat model of gastrointestinal reflux disease (210)

7d), confirming that the need to increase mitochondrial mass in 5FU-treated cells is driven by a dependence on increased mitochondrial activity, and metformin can block this mitochondrial adaptation to prevent drug tolerance in tumours

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