Disclosures: Erick Cruz Grave: Nothing to Disclose, Connie Chan: Nothing to Disclose, Michael Corwin: Corcept Therapeutics: Consultant, Richard Dean: Nothing to Disclose, Sandeep Dhaliwal: Nothing to Disclose, Maryam Yazdanfar: Nothing to Disclose, Christopher Bowlus: Calliditas: Grant/Research Support, ChemoMab: Grant/Research Support, ChemoMab: Consultant, COUR Phamaceuticals: Grant/Research Support, Cymabay: Grant/Research Support, Cymabay: Consultant, Cymabay: Consultant, Gilead: Grant/Research Support, GSK Pharmaceuticals: Grant/Research Support, GSK Pharmaceuticals: Consultant, Hanmi: Grant/Research Support, Intercept: Grant/Research Support, Invea Therapeutics: Consultant, Ipsen: Grant/Research Support, Ipsen: Consultant, Mirum: Grant/Research Support, NGM Bio: Consultant, Novartis: Grant/Research Support, Novo Nordisk: Grant/Research Support, Pliant Therapeutics: Grant/Research Support, Pliant Therapeutics: Consultant, Viking Therapeutics: Grant/Research Support, Zydus Therapeutics: Grant/Research Support 2344 SIGNIFICANCE OF HETEROGENEOUS BILIARY EPITHELIAL SENESCENCE AS A POSSIBLE TARGET OF NEW THERAPIES IN PRIMARY BILIARY CHOLANGITIS Motoko Sasaki 1 Yasunori Sato 1 Yasuni Nakanuma 2 , 1 Kanazawa university, 2 Fukui Saiseikai Hospital Background: New therapeutic strategies are demanded for the patients with primary biliary cholangitis (PBC) showing inadequate response for ursodeoxycholic acid (UDCA) therapy

Once a week, the rats were weighed
This study found that omega-3 PUFAs may be used as a novel therapy for attenuating MTX-induced intestinal injury through its antioxidant, anti-inflammatory, and antiapoptotic effect
Responses of antioxidant enzyme system to copper toxicity and copper detoxification in the leaves of Elsholtzia splendens