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Fibroblast growth factors (FGFs), such as FGF21, show circadian expression and support vascular repair by enhancing VEGF signaling and promoting the activity of endothelial progenitor cells (EPCs) (86, 87).Together, these data suggest that therapeutic strategies targeting both clock components (CLOCK/BMAL1 or PER/CRY) and angiogenic factors (VEGFA/FGF) could enhance BBB recovery and improve outcomes after stroke

M-mode echocardiography was performed as previously described [12]

From this data, it appears that ATM augments x c antiport activity under basal conditions

** Direct Instillation : When used by direct instillation, 1-2 ml of a 20% solution may be given as often as every hour