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To initiate these responses, multiple signals must be integrated in secondary lymphoid organs such as the lymph nodes and spleen 5,9

The product of histone methylation reactions, SAH, is an HMT inhibitor due to its affinity with the catalytic site of HMTs that is equal to or greater than SAM, and SAM/SAH ratios are used as an indicator of methylation activity in cells [68,69,70]