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Interestingly, GPx7 and ERO1 can interact with PDI simultaneously, with ERO1 oxidizing the a domain of PDI, and generating H 2 O 2 that is subsequently used by GPx7 to oxidize the a domain (Wang et al., 2014)

As such, these two NF-B proteins are often termed non-canonical NF-Bs (7)

10.1016/j.ygcen.2010.08.009 Gen

Yuan G, Flores NM, Hausmann S, Lofgren SM, Kharchenko V, Angulo-Ibanez M, Sengupta D, Lu X, Czaban I, Azhibek D, Vicent S, Fischle W, Jaremko M, Fang B, Wistuba II, Chua KF, Roth JA , Minna JD, Shao NY, Jaremko L, Mazur PK, Gozani O