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Statistical analysis methods and biological replicates of each experiment were indicated in the corresponding figure legends

Additionally, sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA), which pumps calcium from the cytoplasm back into the sarcoplasmic/endoplasmic reticulum, is susceptible to oxidation at cysteine-674, resulting in intracellular calcium overload [93]

For both systems, the equilibration and production simulations were computed using the ACEMD3 50 MD engine