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10.1016/j.expneurol.2020.113519 52 GeislerS.DoanR

However, both astrocytes and microglia are now considered to have a wide spectrum of activation phenotypes, and the loss of their neuroprotective functions toward potentially neurotoxic roles is directly related to the stage and severity of the neurodegenerative process ( Microglial cells are able to protect neural tissue against harmful stimuli such as pathogen-associated molecular patterns (PAMPs) and DAMPs, which are recognized by microglia-expressed receptors such as TLRs, oligomerization domain nuclear receptors or viral receptors (Stephenson et al., 2018)

Under normal conditions, cellular ROS production occurs during ATP generation, however, HS exposure tends to induce the production of excessive free radicals, and a decrease in the enzyme activity and concentration of anti-oxidative parameters [42]

doi: 10.1089/10799900360520423