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Notably, the cartilage tissues formed in the PTK hydrogel-treated group were continuous and smooth with thicknesses similar to those of normal joint cartilage tissue

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[12] What little has appeared since is preclinical and mostly concerns engineered analogues rather than DSIP itself for instance, fusion constructs designed to survive in circulation and cross the blood-brain barrier, tested in chemically-induced insomnia models in mice

Evidence also suggests that B12 deficiency can cause inflammation and damage to blood vessels, as well as oxidative stress, which combined can interrupt normal blood flow to the feet (Spence, 2016)