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Typical symptoms & signs of Double-prion Disorders such as ALZ: Loss of communication skills Rapid Memory loss Motor Function, Gait and balance issues, and other symptoms of movement disorders Difficulty making decisions Difficulty with abstract thoughts Faulty reasoning Senile behavior due to cognitive impairment Inappropriate verbal and physical behavior Aphasia Impaired judgment Sundowners Syndrome Autonomic neuropathy Disorientation of time and location Paranoia, frequent agitation, or Hallucinations Complete neglect of personal hygiene and safety People with neurodegenerative Alzheimers might also: Asks the same question repeatedly Cannot recognize family or friends Unable to remember or follow directions Frequent cognitive impairment, i.e., lost or disoriented in very familiar places Sundown Syndrome Sundowning or late-day confusion is a common neurological symptom of Alzheimers

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Lost in translation: treatment trials in the SOD1 mouse and in human ALS