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doi: 10.3390/ijms24010449 127 YamamotoMKenslerTWMotohashiH

The scientific discipline of epidemiology has been the major tool to hypothesize and evaluate genetic, epigenetic, prenatal, perinatal, and environmental factors

In mouse models, increasing ovarian NAD + levels activates SIRT1 signaling, promotes mitochondrial biogenesis, improves energy metabolism, and enhances oocyte quality [303]