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Cleavage of plasmid DNA by AuNPs resulted in the conversion of the compact supercoiled conformation of the plasmid (form I) to the relaxed circular (form II), due to a cut in one of the two strands leading to a remarkable change in mobility of the nicked plasmid during electrophoresis (Mancin et al., Iron oxide nanoparticles are also reported to exhibit catalase enzyme-like activities, however, strong supporting literature has not been developed so far

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The treatment also reshaped the gut microbiota, with correlation analyses indicating that specific bacterial genera associated with TMAO levels were also linked to inflammatory factors and barrier function, underscoring NSPTs role in modulating the oral-gut axis to improve systemic health ( Complementing mechanical therapy, probiotic interventions offer a promising microbial-centric approach