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FIGURE 1 3.2 Zonal distribution of endothelial cells In the liver, apart from the regional distribution of hepatocytes, liver endothelial cells also exhibit significant zonal distribution

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Moreover, it has been shown that gold nanoparticles under 15 nm were able to cross the BBB without any functionalization, probably through the transmembrane or the paracellular pathway, whereas gold particles bigger than 50 nm were not found in the brain [134-136]