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More help Handbook Version v2.0 Graphical Representation A graphical representation of the AOP.This graphic should list all KEs in sequence, including the MIE (if known) and AO, and the pair-wise relationships (links or KERs) between those KEs

In instances of colorectal adenocarcinoma (CAC), alterations affecting the Wnt/-catenin signaling pathway manifest exclusively during advanced disease stages, subsequent to the occurrence of mutations in the TP53 and K-Ras genes (Intarajak et al., 2019)