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In the past couple decades, investigations into PD pathology have revealed some distinct features, such as iron accumulation, lipid peroxidation, glutathione depletion, CoQ10 deficiency, glutathione peroxidase (Gpx4) reduction, mitochondrial lesions, among others 7

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The FcRn mediates both efflux (from the brain to the bloodstream) and potentially influx (from the bloodstream to the brain) transcytosis of IgG, which may have significant implications for the delivery of drugs to the CNS [178]

F., Lobine, D., Akram, M., Riaz, M., Capanoglu, E., Sharopov, F., Martins, N., Cho, W