glutathione synthetase deficiency blood smear as a Cause of Hereditary Hemolytic Disease #imageoftheday, 👉 A 24-year-old man

#imageoftheday, A 24 year old man develops acute jaundice and dark urine after starting trimethoprim sulfamethoxazole. A peripheral smear reveals the specific cellular defects shown. The underlying Rasburicase induced hemolytic anemia in previously undiagnosed G6PD deficiency Constitutional Hematopoietic Disorders Basicmedical Key Megaloblastic Anemia (Folate, Vitamin B12 Deficiency) Clinical Features Vitamin B12 deficiency: Neurological manifestations due to spinal cord involvement, such as difficulty maintaining posture and paresthesia in hands and feet Folate

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