is glutathione heat sensitive stress affects the functionality of the ovine cumulus-oocyte complex and subsequent in vitro embryo production The Biological Functions of Glutathione

This indicated a decrease in GAPDH activity and a concomitant diversion of glucose into the oxidative phase of the pentose phosphate pathway (PPP), a metabolic shift that, upon oxidative stress, helps restore NADPH levels and cellular reducing potential (Figure 1)

Alves CMOS, Marzocchi-Machado CM, Louzada-Junior P, Azzolini AECS, Polizello ACM, de Carvalho IF, et al

A subsequent study also supported the hypothesis that the Asn-43 residue in the canonical tetrahedral metal-binding site in SLC30A10 is important for Mn transport and further demonstrated that residue 43 is a key position in the protein that mediates the inward transmembrane calcium gradient for Mn exchange when expressed in HEK293T cells 90

Nrf2 is required to maintain the self-renewal of glioma stem cells