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Additionally, several single nucleotide polymorphisms (SNPs) have been identified in the CDKN2a/b locus (encoding the p16INK4a , ARF , and p15INK4b transcripts) and associated with multiple age-related pathologies (Jeck et al., 2012

Interaccin con drogas/frmacos El metotrexato, un medicamento utilizado en el tratamiento del cncer, la psoriasis, y la artritis reumatoide, inhibe la enzima dihidrofolato reductasa y, por lo tanto, limita la disponibilidad de grupos metilo donados a partir de derivados de folato