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If left untreated or if it is sudden and severe, affected does will likely experience neurological symptoms due to the lack of glucose in the brain - eye twitching or even blindness, head-pressing or star-gazing, and incoordination - followed by recumbency or sometimes a coma in the terminal stage (2, 6)

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In humans, GPx4 exists in three alternatively spliced isoforms: cytosolic GPx4 (cGPx4), mitochondrial GPx4 (mGPx4) and sperm nucleus GPx4 (snGPx4) [1, 8]

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