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This suggests combining ERO1 inhibition with ferroptosis inducers in the treatment of mTORC1-related cancer to achieve better outcomes

GABA, an inhibitory neurotransmitter, and related nutritional therapies are promising in restoring these imbalances

Despite strong evidence linking gut metabolites to the pathogenesis of CRC, several important limitations still impact our current understanding

4188-A CROSS TALK BETWEEN SIRT6 AND TGF-BETA SIGNALING MODULATE HUMAN NASH-HCC Xiyan Xiang 1 , Xiaochun Yang 1 , Krishanu Bhowmick 1 , Kazufumi Ohshiro 1 , Anil K Vegesna 1 and Lopa Mishra 1,2 , (1)The Institute for Bioelectronic Medicine, Feinstein Institutes for Medical Research, & Cold Spring Harbor Laboratory, Department of Medicine, Division of Gastroenterology and Hepatology, Northwell Health, Manhasset, New York, USA., (2)Center for Translational Medicine, Department of Surgery, the George Washington University, Washington, DC, USA., Washington, DC Background: NASH driven HCC is rising alarmingly in the US