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[DOI] [PubMed] [Google Scholar] 9.Giurgea C, Salama M Nootropic drugs, Progress in Neuro-Psychopharmacology 1977: 1: 235247

First, most of the milder effects fluid retention, a puffy feeling, minor joint stiffness cluster in the activation phase as the axis wakes up, and in the research framing they commonly settle as the body adapts