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TLRs are also involved in promoting functional DNA repair, repairing DNA damage caused by UVB radiation, and stimulating TLR2,3,4,7,8, and 9

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Common side effects for topical corticosteroids include skin atrophy (thin and fragile skin with reduced elasticity), skin blood vessel changes (e.g., spider veins), change in skin color, stretch marks, swelling, dry skin, burning sensation, local irritation, rash, redness, itching, thinning hair or excessive hair growth, infections and allergic reactions

Clinically, these mechanisms emphasize the potential value of combining DOX with autophagy inhibitors, lysosomal function modulators, or regulators of lipid raft integrity to overcome resistance