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Additionally, the anti-Parkinsons drug rotigotine increases striatal astrocytic MT-1/2 and protects nigral DA neurons in a 6-hydroxydopamine (6-OHDA) mouse model of PD through activation of astrocytic 5-HT1A receptors, highlighting its potential as a neuroprotective therapy against dopaminergic degeneration (Isooka et al., 2020)

Intestinal diffusion barrier: unstirred water layer or membrane surface mucous coat

Yang S, Fu Y, Wu X, Zhou Z, Xu J, Zeng X, Kuang N, Zeng Y (2014) Baicalin prevents Candida albicans infections via increasing its apoptosis rate

It also influences melatonin secretion by acting on the pineal gland, promoting circadian rhythm alignment