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Large IOP increases induce ischemia, which compromises the diffusion of glucose, oxygen and lactate through capillary compression, however, even small (3-5 mm Hg) elevations in IOP may result in hypoxia, accumulation of reactive oxygen species and hypoxia-induced factors (e.g., HIF-1 and HIF-2), downregulation of astroglial glutathione content and induction of the autophagosome (117)