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Activated macrophages have been found to overexpress folate receptor (FR), whose binding on the nanoparticle surface can result in active targeted delivery to the tissues of RA [95]

An increasing number of evidences, obtained both from humans and animals, suggests that these contaminants are a major risk factor for morbidity and that they cause, in most cases, renal tubular alterations, specifically in the proximal convoluted tubule, and, sometimes, acute renal failure, which may progress to chronic kidney disease

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