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The Mount Sinai Journal of Medicine, New York, 78 (6), 872881

These pathways are complex and involve communication between peripheral metabolic signals and central nervous system circuits

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FOXO4-DRI effectively counteracted doxorubicin-induced cell senescence and additionally mitigated doxorubicin-induced loss of body mass and elevated levels of aspartate aminotransferase (AST), contributing to the reduction of the hepatotoxicity of the chemotherapy agent [127]