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2 Types and sources of environmental endocrine disruptors Environmental endocrine disruptors represent a heterogeneous collection of chemical substances that fundamentally alter hormone signaling pathways, thereby compromising endocrine homeostasis and reproductive function

The cuproptosis-related gene PDHA1 may serve as a node linking these pathways, regulating lipid metabolism through its interaction with the PI3K-Akt-mTOR signaling pathway [123] (Figure 5)

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