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Survodutide delivers systemic metabolic modulation by activating two receptor systems simultaneously, producing effects on insulin sensitivity, hepatic fat clearance, and energy expenditure that amylin agonism alone can't replicate

EJM and TX-MM-030h were maintained in Iscoves modified Dulbecos medium, supplemented with 20% fetal bovine serum (FBS) and insulin, selenium, transferrin (BD Biosciences) universal culture supplement (1:1000)

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An endometrial biopsy was taken from the inter-caruncle endometrium, digested, plated, and transfected with a pW2 plasmid containing large T and small T antigens 33