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[DOI] [PubMed] [Google Scholar] Artman J

Kim DJ, Kim J, Spaunhurst K, Montoya J, Khodosh R, Chandra K, et al

Biomolecules (2023)

All commercially available CAR-T cell therapies express second-generation CARs containing a single costimulatory domain, whereas third-generation CAR-Ts, which incorporate two costimulatory domains, have demonstrated promising clinical efficacy and remarkably low procedure-specific toxicity in acute lymphoblastic leukemia (153)