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For recreational fitness enthusiasts who are not subject to drug testing, this restriction does not apply, but it is worth knowing

Because AOD 9604 has not completed the full clinical development pathway, its comprehensive side-effect profile in humans is not well characterised and should not be assumed to be benign

Where AOD 9604 targets fat cells directly, tirzepatide works through the incretin system, a network of hormones that regulate appetite, digestion, and insulin secretion from the gut level upward

Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap