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Itami S, Kurata S, Sonoda T, Takayasu S (1995) Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen

Sirtuin 1 (SIRT1) negatively regulates GH-induced IGF-1 production in the liver by directly inhibiting signal transducer and activator of transcription 5 (STAT5) activation, which causes GH resistance under prolonged fasting, starvation, and malnutrition [6]