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foxo4 dri human trials results

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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications FOXO4 DRI improves spermatogenesis in aged mice through reducing senescence associated secretory phenotype secretion from Leydig cells ScienceDirect Huge Week for Anti Aging Research in Mice Hair Loss Cure 2020 CHK2 USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis PNAS

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"Nonetheless, our findings suggest that strengthening oversight and aligning incentives for timely reporting of results from clinical trials outlined in postmarketing requirements and commitments may be necessary to ensure postapproval evidence fulfills its intended role in promoting evidence-based clinical decision-making." JAMA

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