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Taking too much can desensitize the testes, leading to reduced effectiveness over time

Reconstituted working solutions are typically held at 28 C and used within weeks, with aliquoting to minimize freeze-thaw degradation

More rarely, more serious reactions may occur, such as allergic reactions (urticaria, itching, shortness of breath, facial swelling), heart failure in people with pre-existing problems, or hypokalemia (low potassium levels) at the beginning of treatment due to increased hematopoiesis

Though it differs a bit from one person to another, the effects of B12 vitamins usually last around 48 hours to 72 hours after the initial injection