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What about lower amounts of glutamate activity

Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults

Imaging 32 , 5259 (2005)

An association between the presence of PFF and the loss of dopaminergic neurons in the striatum, motor cortex, piriform cortex, somatosensory cortex, amygdala, ventral thalamus, hypothalamus, hippocampus, and spine has been reported in models of intracerebral injection of -syn PFF [44]