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As we age, or when we are exposed to environmental stressors, our natural production of glutathione tends to decline

In mammalian cells the GPx4 protein is found in most subcellular compartments including the cytoplasm, the nucleus, mitochondria, and the endoplasmic reticulum (Arai et al., 1999)

Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, et al: Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals