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[0243] Step-2: (S)-4-nitrophenyl 2,6-bis(tert-butoxycarbonylamino)hexanoate (512.0 mg, 1.095 mmol) in solution in dry DMF (5 mL) was added to a solution of Base Structure (460.6 mg, 0.9127 mmol) and LiOH H 2 0 (40.2 mg, 0.958 mmol)

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310,311,312 DFO and artesunate also act as iron chelators to inhibit ferroptosis

An advantage of using Acuitas Therapeutics was that their ALC-0315 lipid formulation was already available at Polymun which was one of the only companies which had the expertise to immediately combine lipids with mRNA