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Clinical Use of CAR Decreased CAR has been associated with the following conditions: PTSD Chronic Pain Systemic hypertension High CIMT (carotid intima media thickness) in women Functional GI diseases Postpartum depression Chronic Fatigue Syndrome Major depression Insomnia (but not isolated night waking) Autoimmune diseases Atopic and allergic conditions Low frequency noise exposure Low socioeconomic status Perceived high stress Cushing's Disease Addison's Disease Increased CAR is associated with the following conditions: Visceral obesity in men Major depressive episodes Upper respiratory illnesses Bipolar disorder Fibromyalgia in women reporting abuse during childhood Women with BPD (borderline personality disorder) Smoking (to a small degree) Light exposure during waking Chronic stress and worrying Work overload CAR Use in Monitoring Therapy CAR may even be applicable in monitoring the efficacy of drug therapies used to treat these diseases

It inhibits NF-kB activation, reduces pro-inflammatory cytokine Adv Exp Med Biol VIP Vasoactive Intestinal Peptide for Immunomodulation VIP is a 28-amino acid neuropeptide with broad immunomodulatory effects

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