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Yet another study has identified that the 3d mice lacking endosomal TLR signaling due to UNC93B1 mutation, which prevented proper localization of endosomal TLRs, causing high susceptibility to Klebsiella even at sublethal doses ( 5.1 Pathogen post-recognition and downstream signaling Upon engagement of TLRs, either of the two signaling pathways-the MyD88-dependent and TRIF-dependent- associates with a characteristic of TLR2 and TLR4 triggering by microbial pathogens

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Zhang X, Halberstam AA, Zhu W, Leitner BP, Thakral D, Bosenberg MW, et al

However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)