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Below, we briefly review the clinical trial literature

Case 2 A 62-year-old woman was referred for progressing thinning of the hair in the crown area

Furthermore, inflammatory cytokines induce the activation of indoleamine 2,3-dioxygenase (IDO), an enzyme that catalyzes the production of kynurenine from tryptophan, thereby reducing the alternative metabolic pathway that yields 5-HT (Raison et al., 2010